Until lately not too many have people heard about or knew somebody with gluten sensitivity or even celiac disease. Why does this seem to be so widespread now? Answering this question requires a bit of discussion and is by no means a comprehensive treatise on the topic. Perhaps it could be important to understand some terms.
I’m frequently asked what is the difference between gluten sensitivity, gluten allergies and celiac disease. Most experts concur that for you to be diagnosed with an allergy, you want to have an immune response that contains the antibody named immunoglobulin E (IgE) and the subsequent release of histamine by a category of white blood cells called mast cells. This sort of allergic reaction is instantaneous and often can be acute.
The most severe reaction is called an anaphylactic reaction and may be life threatening. If you have this type of allergy you definitely know it and likely carry an EpiPen around with you. Gluten or another food sensitivity typically means that the victim has an immune reaction with another set of antibodies.
These antibodies are known as immunoglobulin A (IgA) or immunoglobulin G (IgG). When you’re diagnosed with a gluten sensitivity your testing could reveal you’re responding to a chemical in wheat, rye, barley. Realizing you have an IgA or IgG sensitivity can be more mysterious as there are numerous symptoms you can get that many instances are attributed to another cause. The mistaken attribution is often because of a delay between the time of ingestion of the food you’re sensitive too, or because of the gentle nature of a response in the time which you chalk up to “just the way you’re”.
It refers to the destruction of your small intestinal villi, which are the finger-like projections of your gut cells by your immune system. Imagine a piece of shag carpeting rolled into a tube with the shags facing inward and you’ve got some idea of how the small intestine appears on a microscopic level. Now imagine your immune system has a fleet of lawnmowers that wrongly mow off all of the shags down to nubs.
That is celiac disease – and the ending point destruction is known as total villous atrophy (TVA). Due to the shortage of villi you can’t absorb nutrients in adequate quantity and because of this several different diseases or conditions can create like osteoporosis or iron deficiency, depression, abnormal results on liver blood tests and much, much more. Here’s a super important point to take to heart: gluten sensitivity and celiac disease BOTH are permanent intolerances to ingested gluten that results in immunologically mediated inflammatory damage to the small-intestinal cells.
De nos jours,
Why is gluten sensitivity apparently more prevalent nowadays? To start with, more advanced testing is currently available, making the diagnosis more precise with blood tests or with saliva tests. The gold standard for detecting celiac disease was a blood test for IgA response to alpha gliadin and 3 biopsies (gliadin is a glycoprotein present in wheat and lots of other cereals in the marijuana genus Triticum). The issue with this “gold standard” test is that nearly total villous atropy (TVA) was necessary before the test became positive.
In reality celiac disease patients are normally 10-15 times more likely to exhibit IgA deficiency in the blood! Since the arrival of improved testing (saliva IgA and IgG and analyzing more that just alpha gliadin) and consciousness that gluten sensitivity and celiac disease is more widespread than previously believed, has led clinicians to search for these disorders in their clinical workup. In my practice I’ve found nearly 100 percent of those patients who come to me with chronic health issues (like fibromyalgia, hypothyroidism and equilibrium disorders, etc.) have gluten sensitivity.
Bon à savoir
Our immune system reacts with increased ferver to deamidated gliadin compared to gliadin. The typical US storage period for harvested wheat is roughly two decades! During this storage period the waste products of fungi and mould form that are called enterotoxins. Enterotoxins and be defined as a toxin produced by bacteria which is specific for intestinal cells and results in the nausea and diarrhea associated with food poisoning.
The enterotoxins result in a leaky gut that triggers an immune response to the gluten that’s contaminated. Leaky Gut Syndrome LGS is a autoimmune condition in which the walls of the intestines are damaged to the point where they no longer function to maintain food molecules, bacteria and other undesirable material from getting into the blood stream. As a consequence of the foreign substance entering the blood stream, the immune system is triggered and undamaged gluten molecules or some of the additional wheat breakdown products are targeted for destruction, as are the cells of the intestines. The next wheat derivatives would be the target of a number of the technical testing other like-minded physicians and I offer to discover gluten sensitivity.
It alters how our immune system works and may result in autoimmune disease such as celiac disease, diabetes and other disorders. Chronic stress limits your body’s ability to produce the antibodies needed to fight off pathogens. It suppresses the T-cells or lymphocytes allowing germs to move quickly. Elevated levels of cortisol also damage the part of the body which produce immune cells. These pieces are the spleen, lymph nodes, and the thymus gland. Poor nutrition results in multiple vitamin and mineral deficiencies. In case you were not aware vitamins and minerals are used in the multitude of chemical reactions that your body’s enzymes carry out on a daily and nightly basis.
Obviously all those wheat established carbohydrates will activate an immune reaction against gluten in people with the predisposition (individuals with celiac or gluten senstivity genes). A vast majority of Americans with northern European descent will test positive for celiac or gluten senstivity genes. I tested positive for one celiac gene and a single gluten sensitvitiy gene as well as my wife tested positive for 2 gluten sensitiviety genes. Because of this all our kids will have some mix of thee genes also.